Endocrine Abstracts

Background: In recent years, continuous glucose monitoring (CGM) has emerged as a method for the assessment of glycemic control. Also CGM enables diabetic patients to understand their own blood glucose status and change their lifestyle.Aims: We investigated the effect of CGM on the glycemic control in Korean type 2 diabetic patients.Methods: We enrolled type 2 diabetic patients who met all the following criteria: 1) use of oral ant...

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This study was performed to investigate the effects of LY2405319, an analogue of fibroblast growth factor 21 (FGF21), on glucose homeostasis in streptozotocin (STZ)-induced insulin-deficient mice. Nine-week-old male C57BL/6J mice were administered a single intraperitoneal injection of STZ (150 mg/kg). One week later, after confirmation of hyperglycaemia, saline or LY2405319 (5 mg/kg) was injected subcutaneously daily for 4 weeks. The STZ-induced diabetic mice had elevated bloo...

Background: To predict severe acute pancreatitis (AP) at early stage is important to reduce morbidity and mortality. We aimed to investigate the association between the triglyceride and glucose index (TyG index) and the prognosis of acute pancreatitis.Methods: The TyG index was calculated as the ln[fasting triglycerides (mg/dl) × fasting plasma glucose (mg/dl)]/2. Patients were then categorized into low TyG index group (<5) and high TyG index gr...

In males androgens are primarily made by testicular Leydig cells and act as essential regulators of both fetal masculinization and adult reproductive function. The impact of androgens on gene transcription is largely mediated by the androgen receptor (AR), a member of the steroid hormone super-family of ligand activated transcription factors. AR is expressed widely throughout the body, including several key somatic cell-types in the testis. Although we have known for many year...

In males androgens are primarily made by testicular Leydig cells and act as essential regulators of both fetal masculinization and adult reproductive function. The impact of androgens on gene transcription is largely mediated by the androgen receptor (AR), a member of the steroid hormone super-family of ligand activated transcription factors. AR is expressed widely throughout the body, including several key somatic cell-types in the testis. Although we have known for many year...

Fibrous dysplasia (FD) is a focal bone lesion composed of immature mesenchymal osteoblastic precursor cells which may occur at one site (monostotic) or multiple sites (polyostotic) in individual patients. Polyostotic FD may also be associated with other manifestations, including hyperpigmented (café-au-lait) skin lesions, gonadotropin-independent sexual precocity, and/or other endocrine and nonendocrine manifestations, and these constellation of features are known as the ...

Childhood onset Type 2 diabetes mellitus is appearing in Asia. Sadly, the risk factors appear to be obesity, a sedentary lifestyle, and a family history of type 2 diabetes mellitus or gestational diabetes and IUGR. Comorbidities include abnormal lipid profiles, steatohepatitis, hypertension for age and obstructive sleep apnoeaModalities of treatment include diet, exercise, insulin, metformin, and sulphonylureas and more recently, the use of insulin sens...

Introduction: The thyrotrophic effects of human chorionic gonadotrophin (HCG) are responsible for a physiological rise in fT4 and suppression of TSH in early pregnancy. Hyperthyroidism in this period is mostly due to gestational transient thyrotoxicosis (GTT) which is frequently mild and resolves spontaneously by 18 weeks, or due to Graves’ disease (GD) which would require closer monitoring through pregnancy (1). The pathophysiology of hyperemesis gravidarum is unclear, a...

Introduction: The valuable and innovative work carried out by Paediatric Endocrine Nurses is not always recognised. The Ipsen BSPED Endocrine Nurse prize provides this group with a valuable platform to promote expertise and best practice; not just within their group but also to the wider multi-disciplinary team.Discussion: Paediatric Cushing’s syndrome (CS) is a very rare, life threatening disorder and the diagnosis/treatment of this condition is ex...